张峻峰 博士、教授
国家杰出青年基金获得者
长江学者特聘教授
博士生导师
办公室： A-431
联系电话：025-89682502
电子邮箱：jfzhang@nju.edu.cn
教育及工作经历
1993-1995中日联合培养在日本京都大学再生医学研究所学习并获博士学位
1997-2000在新加坡国立大学作研究访问学者
2001年至今担任南京大学生命科学学院教授
讲授课程
《体内药物输送》
《化学、生物学与新药发现》
获奖情况
1.2012年长江学者特聘教授
2.2011年教育部科学技术一等奖
3.2010年国家杰出青年科学基金
4.2004年国家自然科学二等奖
5.2003年教育部科学技术一等奖
代表论文与著作
1.Zhang, Z., C. Wang, Y. Zha, W. Hu, Z. Gao, Y. Zang, J. Chen, J. Zhang and L. Dong (2015). Corona-directed nucleic Acid delivery into hepatic stellate cells for liver fibrosis therapy. ACS Nano 9(3): 2405-2419.
2.Tu, X., H. Zhang, J. Zhang, S. Zhao, X. Zheng, Z. Zhang, J. Zhu, J. Chen, L. Dong, Y. Zang and J. Zhang (2014). MicroRNA-101 suppresses liver fibrosis by targeting the TGF-β signalling pathway. J Pathol 234(1): 46-59.
3.Huang, Z., T. Shi, Q. Zhou, S. Shi, R. Zhao, H. Shi, L. Dong, C. Zhang, K. Zeng, J. Chen and J. Zhang (2013). miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12beta during murine colitis and human Crohn's disease. Gut. 63:1247-57;
4.Zhang, Z., Z. Gao, W. Hu, S. Yin, C. Wang, Y. Zang, J. Chen, J. Zhang and L. Dong (2013). 3,3'-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression. Br J Pharmacol 170(3): 649-660.
5.Li, J., Y. Zhang, Y. Liu, X. Dai, W. Li, X. Cai, Y. Yin, Q. Wang, Y. Xue, C. Wang, D. Li, D. Hou, X. Jiang, J. Zhang, K. Zen, X. Chen and C. Y. Zhang (2013). Microvesicle-mediated transfer of microRNA-150 from monocytes to endothelial cells promotes angiogenesis. J Biol Chem 288(32): 23586-23596.
6.Yao, Z., W. Hu, S. Yin, Z. Huang, Q. Zhu, J. Chen, Y. Zang, L. Dong and J. Zhang (2013). 3,3'-Diindolymethane ameliorates adriamycin-induced cardiac fibrosis via activation of a BRCA1-dependent anti-oxidant pathway. Pharmacol Res 70(1): 139-146.
7.Wang, R., Z. Wang, Y. Ma, G. Liu, H. Shi, J. Chen, L. Dong, J. Zhao and J. Zhang (2013). Particle-induced osteolysis mediated by endoplasmic reticulum stress in prosthesis loosening. Biomaterials 34(11): 2611-2623.
8.Sun, D., F. Yu, Y. Ma, R. Zhao, X. Chen, J. Zhu, C. Y. Zhang, J. Chen and J. Zhang (2013). MicroRNA-31 activates the RAS pathway and functions as an oncogenic MicroRNA in human colorectal cancer by repressing RAS p21 GTPase activating protein 1 (RASA1). J Biol Chem 288(13): 9508-9518.
9.Huang, Z., Y. Yang, Y. Jiang, J. Shao, X. Sun, J. Chen, L. Dong and J. Zhang (2013). Anti-tumor immune responses of tumor-associated macrophages via toll-like receptor 4 triggered by cationic polymers. Biomaterials 34(3): 746-755.
10.Yang, C., C. Wang, X. Chen, S. Chen, Y. Zhang, F. Zhi, J. Wang, L. Li, X. Zhou, N. Li, H. Pan, J. Zhang, K. Zen, C. Y. Zhang and C. Zhang (2013). Identification of seven serum microRNAs from a genome-wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas. Int J Cancer 132(1): 116-127.
11.Huang, Z., L. Dong, J. Chen, F. Gao, Z. Zhang, J. Chen and J. Zhang (2012). Low-molecular weight chitosan/vascular endothelial growth factor short hairpin RNA for the treatment of hepatocellular carcinoma. Life Sci 91(23-24): 1207-1215.
12.Huang, Z., Z. Zhang, Y. Zha, J. Liu, Y. Jiang, Y. Yang, J. Shao, X. Sun, X. Cai, Y. Yin, J. Chen, L. Dong and J. Zhang (2012). The effect of targeted delivery of anti-TNF-alpha oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice. Biomaterials 33(30): 7605-7612.
13.Luo, Y., Z. Pang, Q. Zhu, X. Cai, Y. Yin, M. Wang, J. Zhu, J. Chen, K. Zeng, C. Zhang and J. Zhang (2012). Locally instilled tumor necrosis factor-α antisense oligonucleotide inhibits allergic inflammation via the induction of Tregs. J Gene Med 14(6): 374-383.
14.Chen, X., H. Liang, J. Zhang, K. Zen and C. Y. Zhang (2012). Horizontal transfer of microRNAs: molecular mechanisms and clinical applications. Protein Cell 3(1): 28-37.
15.Chen, X., H. Liang, J. Zhang, K. Zen and C. Y. Zhang (2012). Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol 22(3): 125-132.
16.Zhou, G., X. Cheng, S. Wu, X. Jiang, X. Shi, J. Chen, J. Zhang and J. Zhao (2012). Preparation and antitumor activity of a polymeric derivative of methotrexate. Am J Med Sci 344(4): 294-299.
17.Huang, Z., Z. Zhang, Y. Jiang, D. Zhang, J. Chen, L. Dong and J. Zhang (2012). Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy. J Control Release 158(2): 286-292.
18.Zhang, L., D. Hou, X. Chen, D. Li, L. Zhu, Y. Zhang, J. Li, Z. Bian, X. Liang, X. Cai, Y. Yin, C. Wang, T. Zhang, D. Zhu, D. Zhang, J. Xu, Q. Chen, Y. Ba, J. Liu, Q. Wang, J. Chen, J. Wang, M. Wang, Q. Zhang, J. Zhang, K. Zen and C. Y. Zhang (2012). Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res 22(1): 107-126.